Your idea is certainly an interesting one, and deserving a closer look. I have some reservations about the blue-zone angle. One reason for the extraordinary life-expectancy could also be a specific genetic variant that dominates within these populations AND for which their dietary and other lifestyle patterns are an ideal match. But that is just a suspicion. It is probably difficult to prove, or at least only with very considerable labor and expense.

I’d rather advocate for the opposite way of investigating the blue-zone life-expectancy patterns: Find enough people having adopted the same or very similar lifestyle patterns in other parts of the world, use them as the control group and compare their life- and health expectancy with the blue-zone inhabitants.

Either one of those investigations can deliver definite evidence. But that, I’m afraid is a long way off.

But then again, viral and other infections trigger an inflammatory response, that, if it persists in a chronic state, negatively affects vascular health and function.

Totally avoiding infections, or at least dialing them down considerably, might promote excess reaction to future infections (which are not totally avoidable) as we have seen post-COVID lockdowns.