You are absolutely right, Georgios, sedentary lifestyle expose to a higher CVD risk. The problem with the measurement of exercise volume is, that it only indirectly reflects the more reliable predictor of healthy longevity: cardiorespiratory fitness and muscle strength and mass. These are, however, too impractical to measure in daily medical practice, which is why these are not part of the risk algorithms, at least not of those that constitute the U-Prevent risk calculators. And, yes, in the context of a sedentary lifestyle the justification for aspirin is higher, as the CVD risk is elevated.