The answer isn't easy or straight forward. The studies on the effects of Q supplementation are inconclusive. Some meta-analyses suggest that Q supplements might lower LDL and raise HDL "significantly", but when you look at the values, their statistical significance belies clinical irrelevance, because the effect is too small.

For curcumin the situation is similar. You can increase its bioavailability by adding black pepper or its active ingredient piperine to increase bioavailability, but whether increased bioavailability translates into clinically relevant results is an open question.

With respect to MCAS (mast cell activation syndrome) I'm not the best addressee for your question. First, because that aspect of immunology is not within my key competencies, and second because MCAS is somewhat difficult to diagnose due to the heterogeneity of presentations and the non-specificity of symptoms.