Thanks, Georgios, for your thoughtful comment. Recent studies have shown that micro- and nanoplastics (MNPs) can cross the blood-brain barrier and potentially have neurotoxic effects. There is a parallel with metal and metal-oxide nanoparticles, such as gold (Au) and titanium dioxide (TiO2) nanoparticles. Like them, MNPs are chemically inert, which is why they accumulate in the environment in the first place. These nanoparticles can reach the brain and exert a range of neurotoxic effects, such as the induction of oxidative stress, altered neurotransmitter levels, and others. MNPs may also influence protein folding and potentially trigger amyloidosis. which could have implications for neurodegenerative diseases (Windheim et al., 2022).