Thanks, Georgios, for your kind appreciation and for your questions.

Ozempic seems to become a miracle drug that can't do any wrong, and shows up so many benefits. Hardly a day goes by in which my publication radar doesn't connect Ozempic to some health benefits. I'm always skeptical when exuberance is so great. We've had this situation for several other drugs in the past. That's why we need the so-called phase IV trials, that is, data following a drug's introduction inot the market. Only once a drug has hit the market and has been used by a number of people far in excess of what is done in phase I-III trials, can we see the potential side effects. We are far from having those data because, while Ozempic has been in the market for a while, it has only been used on diabetics, not on otherwise healthy people who want to lose weight. So, the jury is still out on that.

Psyllium has been studied as an add-on in diabetics and patients with metabolic syndrome (probably inother scenario, too). It's a fiber that adds bulk to co-ingested foods, thereby increasing satiety (to a point). It doesn't ferment in the large intestine which is why I suspect it does not promote a shift of the constituents of the microbiome towards those that produce short-chain fatty acids (like butyrate) . So I would expect it to be less effective compared to resistant starch.