Thanks, George, and I’m naturally impressed. I’m also on the wrong side of 60, but 100 lb dumbbell flys are beyond my capability.

Now, allow me to say something to the Horvath clock (which applies to all methylation clocks). We have yet to find out whether the methylation patterns are “innocent bystanders”, that is they correlate with biological age, or whether their modification drives the slowing down or acceleration of aging. Because we simply don’t know what effects the methylation patterns have on gene expression. That’s a purely scientific question, which is of course very interesting. But I’m more interested in using applicable science. That’s why I prefer Belsky’s DunedinPACE rate of aging clock (I’m not sure whether you are into reading science papers. If you are here is a link to a relevant full-text paper https://elifesciences.org/articles/73420).

Rate of aging is, in my eyes, a much better tool for self-experimenting than taking snapshots, which is what all the methylation clocks do. Moreover, if you do self-experiments in the trial-and-error way, you’ll need ideally daily real-time feedback on the biomarker of the rate of aging. This feedback is required for the statistical method that underlies the N-of-1 method (N-of-1 is the FDA and EMA recognized gold standard for performing clinical trials with one person). On the home page of our website you’ll find 3 short explanatory videos, one of which is about N-of-1.

What my team and I have done is to develop a rate-of-aging marker that is based on vascular function (PWV, pulse wave velocity, also the subject of one of the 3 videos). We have derived the algorithm from several hundred persons. We also published a paper about its predecessor, our robustness score (https://www.sciencedirect.com/science/article/pii/S2211335518300081?via%3Dihub).

The next step was to use a layperson-capable tool to measure PWV and translate its output into a rate of aging score. We have done that using the Withings Body Cardio scale. Withings is currently the only company that has a layperson capable and affordable technology on the market (the scale costs somewhere between 150 and 190 US$). BTW, I have no affiliation with Withings and don’t gain anything when I recommend their product.

So, if you are interested to perform your N-of-1 self-experiments in a more formalized way, and if you want to use that Withings scale, then I offer you to use our web application (not an app that runs on your phone) as a trial subject.

So, read up on it and let me know. And of course, no strings attached. In my article about bioage you can read about the Belsky clock and our rate of aging approach: https://medium.com/illumination-curated/embrace-your-bioage-abandon-your-calendar-age-say-scientists-7430eff3830f