Thanks for your insightful comment, Ted. I have addressed the need for individualization in a post in which I demonstrate how, despite partial non-adherence to the AHA's Life's Essential-8 people can make it healthily into their 90s (https://medium.com/right-to-rejuvenation/cvd-risk-factors-may-actually-not-kill-you-or-make-you-sick-the-stunning-statistics-e1c835d30f6a). Case in point: comedian George Burns, who smoked 10 cigars every day and was still acting at age 99.

Or 109-year-old Mr. Overton, who still smoked his cigars at that age (https://medium.com/right-to-rejuvenation/a-digital-science-kit-for-healthy-longevity-beating-the-odds-of-lifes-essential-8-35ad0ba2229e).

But these are the rare exceptions of people who are robust enough to withstand that type of assault.

It perfectly fits into the phenomenon of robustness of complex systems: "robust yet fragile" i.e. robust against some insults, but fragile against others. The problem is that we can't know beforehand. Not with the human organism.