Thanks, David, for your kind appreciation and for sharing experience and your thoughts. I have to admit that I'm too little into other fields of science to make an educated comment on your suspicion that not only medicine is affected by VoE. Though I wouldn't be surprised if thatis is the case. I don't expect VoE to be an issue in physics or chemistry for example, where well understood natural laws rule. Medicine, physiology, and probably other segments of biology, are prone to it because the complexity of the investigated organisms complicates straight-forward predictions based on generalized rules.